منابع مشابه
Chromosome breakage and repair.
FROM time to time one of my colleagues working at a medical school commiserates with me because I spend 40 hr a year lecturing to undergraduates. I always reply that teaching has compelled me to learn a lot of material that I would not have known about had I taught only my specialized subject. These forays into the ‘‘beyond’’ were instrumental in moving my research in new directions. Three arti...
متن کاملChromosome breakage and ultrasound.
Human lymphocyte cultures were examined for chromosome damage after exposure to ultrasound. Control and treated slides were scored "blind" and showed no evidence of damage due to ultrasound. Neither was there evidence of chromosome damage in blood cultures from six infants whose mothers had ultrasound during pregnancy when compared with that from six infants whose mothers had not. Our results s...
متن کاملThe Fragile Breakage versus Random Breakage Models of Chromosome Evolution
For many years, studies of chromosome evolution were dominated by the random breakage theory, which implies that there are no rearrangement hot spots in the human genome. In 2003, Pevzner and Tesler argued against the random breakage model and proposed an alternative "fragile breakage" model of chromosome evolution. In 2004, Sankoff and Trinh argued against the fragile breakage model and raised...
متن کاملChromosome breakage following G2 checkpoint release
DNA double-strand break (DSB) repair and checkpoint control represent distinct mechanisms to reduce chromosomal instability. Ataxia telangiectasia (AT) cells have checkpoint arrest and DSB repair defects. Here, we examine the efficiency and interplay of ATM's G2 checkpoint and repair functions. Artemis cells manifest an identical and epistatic repair defect to AT but show proficient checkpoint ...
متن کاملChromosome breakage after G2 checkpoint release
DNA double-strand break (DSB) repair and checkpoint control represent distinct mechanisms to reduce chromosomal instability. Ataxia telangiectasia (A-T) cells have checkpoint arrest and DSB repair defects. We examine the efficiency and interplay of ATM's G2 checkpoint and repair functions. Artemis cells manifest a repair defect identical and epistatic to A-T but show proficient checkpoint respo...
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ژورنال
عنوان ژورنال: Genetics
سال: 2006
ISSN: 1943-2631
DOI: 10.1093/genetics/173.3.1181